Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia
نویسندگان
چکیده
منابع مشابه
Silent subcortical brain infarction
Introduction: The silent brain lesions detected by MRI were fairly common not only in first-ever stroke but also in normal elderly subjects. Some recent studies show the possible role of silent sub-cortical brain infarction in ischemic stroke. The aim of this study was to evaluate the frequency of silent sub-cortical brain infarction in acute first-ever ischemic stroke. Methods: In this descrip...
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OBJECTIVE Rho-associated kinase (ROCK) is a key regulator of numerous processes in multiple cell types relevant in stroke pathophysiology. ROCK inhibitors have improved outcome in experimental models of acute ischemic or hemorrhagic stroke. However, the relevant ROCK isoform (ROCK1 or ROCK2) in acute stroke is not known. METHODS We characterized the pharmacodynamic and pharmacokinetic profile...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Imaging
سال: 2012
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2012.01.025